The ZNF395 Polyclonal Antibody (PACO19749) is a valuable tool for research involving the zinc finger protein ZNF395, a transcription factor essential for regulating gene expression. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the ZNF395 protein, it enables accurate detection and analysis in a variety of cell types, making it an ideal choice for studies in molecular biology and gene regulation.ZNF395 is known for its role in controlling the expression of genes involved in various cellular processes, including cell proliferation, differentiation, and apoptosis.
Its importance in gene regulation makes it a key target for research in fields such as cancer biology, developmental biology, and stem cell research. Understanding the function of ZNF395 is crucial for uncovering its impact on cellular pathways and potentially identifying novel therapeutic targets for various diseases.Overall, the ZNF395 Polyclonal Antibody (PACO19749) is a valuable tool for researchers investigating the role of ZNF395 in gene regulation and cellular processes. Its high reactivity and specificity make it a reliable option for Western blot analysis, providing valuable insights into the function of ZNF395 in various biological contexts.
Antibody Name:
ZNF395 Antibody (PACO19749)
Antibody SKU:
PACO19749
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human ZNF395
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO19749(ZNF395 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. As a member of the krueppel C2H2-type zinc-finger protein family, ZNF395 (Zinc finger protein 395), also known as PBF (Papillomavirus-binding factor) and HDBP2 (Huntington disease gene regulatory region-binding protein 2), is a 513 amino acid, protein that contains one C2H2-type zinc finger. ZNF395 binds to the 3Â’-CCGG-5Â’ sequence within the papillomavirus promoter adjacent to a RUNX1-binding motif. It has also been established that ZNF395 binds to a seven base pair region within the Huntington's disease (HD) gene promoter, an essential element for HD gene expression. ZNF395 is widely expressed and probably shuttles between the nucleus and cytoplasm.
Synonyms:
zinc finger protein 395
UniProt Protein Function:
ZNF395: Plays a role in papillomavirus genes transcription.Protein type: Transcription factor; C2H2-type zinc finger proteinChromosomal Location of Human Ortholog: 8p21.1Cellular Component: cytoplasm; nucleusMolecular Function: DNA bindingBiological Process: regulation of transcription, DNA-dependent
