Description
ZRANB2 Antibody (PACO01723)
The ZRANB2 Polyclonal Antibody (PACO01723) is a valuable tool for researchers studying ZRANB2, a protein involved in DNA repair and genome stability. This antibody, raised in rabbits, is highly specific to human ZRANB2 and is suitable for use in Western blot and immunohistochemistry applications. By binding to ZRANB2, this antibody facilitates the detection and analysis of this protein in a variety of cell types, making it an essential component in studies related to DNA damage response and genome maintenance.ZRANB2 is a key player in the DNA repair pathway, specifically in homologous recombination and replication fork stability. Dysregulation of ZRANB2 has been linked to genomic instability and increased susceptibility to cancer development.
By targeting ZRANB2 with this antibody, researchers can gain insights into the mechanisms underlying DNA repair processes and potential therapeutic strategies for cancer treatment.Overall, the ZRANB2 Polyclonal Antibody (PACO01723) serves as a crucial tool for investigating the role of ZRANB2 in DNA repair pathways and its implications for cancer biology. Its high specificity and reactivity make it a valuable resource for researchers aiming to unravel the complexities of genome maintenance and uncover novel therapeutic targets in the field of cancer research.
| Antibody Name: | ZRANB2 Antibody |
| Antibody SKU: | PACO01723 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | synthesized peptide derived from the Internal region of human ZIS. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | ZRANB2; ZIS; ZNF265; Zinc finger Ran-binding domain-containing protein 2; Zinc finger protein 265; Zinc finger; splicing |
| UniProt Protein Function: | ZNF265: Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'- splice site selection. Belongs to the ZRANB2 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:RNA-binding Chromosomal Location of Human Ortholog: 1p31 Cellular Component: nucleoplasm; nucleus Molecular Function:protein binding; RNA binding; transcription factor activity; zinc ion binding Biological Process: mRNA processing; regulation of transcription, DNA-dependent; RNA splicing |
| UniProt Code: | O95218 |
| NCBI GenInfo Identifier: | 146291106 |
| NCBI Gene ID: | 9406 |
| NCBI Accession: | O95218.2 |
| UniProt Secondary Accession: | O95218,Q53GS3, Q59F92, Q5VV33, Q5VV34, Q8IXN6, Q9UP63 D3DQ75, |
| UniProt Related Accession: | O95218 |
| Molecular Weight: | 36,318 Da |
| NCBI Full Name: | Zinc finger Ran-binding domain-containing protein 2 |
| NCBI Synonym Full Names: | zinc finger RANBP2-type containing 2 |
| NCBI Official Symbol: | ZRANB2Â Â |
| NCBI Official Synonym Symbols: | ZIS; ZIS1; ZIS2; ZNF265Â Â |
| NCBI Protein Information: | zinc finger Ran-binding domain-containing protein 2 |
| UniProt Protein Name: | Zinc finger Ran-binding domain-containing protein 2 |
| UniProt Synonym Protein Names: | Zinc finger protein 265; Zinc finger, splicing |
| Protein Family: | Zinc finger Ran-binding domain-containing protein |
| UniProt Gene Name: | ZRANB2Â Â |
| UniProt Entry Name: | ZRAB2_HUMAN |
