The AASS Polyclonal Antibody is a valuable tool for researchers studying AASS, a key enzyme involved in the biosynthesis of amino acids. This antibody, produced in rabbits, is highly specific to human samples and is suitable for use in various applications, including Western blotting. By targeting the AASS protein, this antibody allows for the detection and analysis of AASS in different cell types, making it an essential tool for studies in biochemistry and metabolism.AASS, also known as aminoadipate-semialdehyde synthase, plays a crucial role in the metabolic pathway responsible for producing lysine, an essential amino acid.
Dysregulation of AASS activity has been linked to various metabolic disorders and diseases, making it a promising target for therapeutic interventions. By understanding the function of AASS, researchers can gain insights into the molecular mechanisms underlying these conditions and potentially develop new treatment strategies.
Product Name:
AASS Polyclonal Antibody
SKU:
CAB24544
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 480-600 of human AASS (NP_005754.2).
Sequence:
RRKV LVLG SGYI SEPV LEYL SRDG NIEI TVGS DMKN QIEQ LGKK YNIN PVSM DICK QEEK LGFL VAKQ DLVI SLLP YVLH PLVA KACI TNKV NMVT ASYI TPAL KELE KSVE DAGI TIIG E
This gene encodes a bifunctional enzyme that catalyzes the first two steps in the mammalian lysine degradation pathway. The N-terminal and the C-terminal portions of this enzyme contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively, resulting in the conversion of lysine to alpha-aminoadipic semialdehyde. Mutations in this gene are associated with familial hyperlysinemia.
Purification Method:
Affinity purification
Gene ID:
10157
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from Rat kidney, using AASS Rabbit pAb (CAB24544) at 1:100 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
