The ABCC13 Monoclonal Antibody (PAC023467) is a crucial tool for researchers studying the ABCC13 protein, a member of the ATP-binding cassette (ABC) transporter superfamily. This antibody, produced in mice, is highly specific to human samples and has been validated for use in various applications, including immunohistochemistry and flow cytometry.ABCC13 plays an essential role in drug metabolism and transport, making it a target of interest in pharmacology and toxicology research. It is involved in the transport of various molecules across cell membranes, impacting drug efficacy, toxicity, and resistance.
By using this antibody, researchers can detect and analyze ABCC13 expression in different cell types and tissues, aiding in the understanding of its function in health and disease.The ABCC13 Monoclonal Antibody is a valuable tool for investigations into drug interactions, drug resistance mechanisms, and personalized medicine approaches. Its high specificity and sensitivity make it a reliable choice for scientists studying ABCC13's role in various biological processes and its potential as a therapeutic target.
Synthesized peptide derived from internal of human ABCC13.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from 293 cells, COLO cells and HT-29 cells, using ABCC13 antibody.
Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue using ABCC13 antibody.
Background:
This gene is a member of the superfamily of genes encoding ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This family member is part of the MRP subfamily, which is involved in multi-drug resistance, but the human locus is now thought to be a pseudogene incapable of encoding a functional ABC protein. Alternative splicing results in multiple transcript variants; however, not all variants have been fully described.
Synonyms:
ABCCD; ATP-binding cassette protein C13; PRED6;
UniProt Protein Function:
ABCC13: a member of the superfamily of genes encoding ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This family member is part of the MRP subfamily, which is involved in multi-drug resistance, but the human locus is now thought to be a pseudogene incapable of encoding a functional ABC protein. Alternative splicing results in multiple transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]Protein type: Transporter; Membrane protein, integral; Hydrolase; Transporter, ABC family; Membrane protein, multi-passChromosomal Location of Human Ortholog: 21q11.2Cellular Component: integral to membraneMolecular Function: ATPase activity, coupled to transmembrane movement of substances; ATP bindingBiological Process: transmembrane transport
