The ADAM22 Antibody (CAB10030) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the ADAM22 protein, this antibody enables the detection and analysis of ADAM22 expression in various cell types, making it an ideal choice for studies in neurobiology and neuroscience research.ADAM22 plays a crucial role in mediating synaptic transmission and regulating neuronal function, making it a key player in processes such as synaptic plasticity and learning and memory. Dysfunction of ADAM22 has been linked to neurological disorders such as epilepsy and schizophrenia, highlighting the importance of understanding its molecular mechanisms and signaling pathways.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Mouse, Rat samples.
Product Name:
ADAM22 Antibody
SKU:
CAB10030
Size:
20μL, 100μL
Reactivity:
Mouse, Rat
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:
MDC2, DEE61, EIEE61, ADAM 22, ADAM22
Positive Sample:
SH-SY5Y, Mouse brain, Mouse kidney, Mouse heart, Rat kidney, Rat heart
Cellular Localization:
Cell Projection, Membrane, Single-Pass Type I Membrane Protein, Axon.
Calculated MW:
100kDa
Observed MW:
100kDa
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Unlike other members of the ADAM protein family, the protein encoded by this gene lacks metalloprotease activity since it has no zinc-binding motif. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. In mice, it has been shown to be essential for correct myelination in the peripheral nervous system. Alternative splicing results in several transcript variants.
Purification Method
Affinity purification
Gene ID
53616
RRID
AB_2757551
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates using ADAM22 Rabbit pAb (CAB10030) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 1s.
