The ADCY6/ADCY5 Antibody (PAC023304) is a valuable tool for researchers studying ADCY6 and ADCY5, two important adenylate cyclase enzymes involved in cAMP signaling pathways. This polyclonal antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to ADCY6 and ADCY5 proteins, this antibody enables the detection and analysis of these enzymes in a variety of cell types, making it ideal for studies in cell signaling and signal transduction research.ADCY6 and ADCY5 are key players in intracellular signaling cascades that regulate various physiological processes, including hormone secretion, neurotransmission, and cell growth.
Dysregulation of these enzymes has been implicated in a range of diseases, such as metabolic disorders, cardiovascular diseases, and neurological disorders. Understanding the function and regulation of ADCY6 and ADCY5 is essential for developing targeted therapies that modulate cAMP signaling pathways in these disease contexts.Overall, the PAC023304 antibody offers researchers a reliable tool for studying the roles of ADCY6 and ADCY5 in health and disease, providing important insights into the mechanisms of cAMP signaling and potential therapeutic targets for a variety of disorders.
Synthesized peptide derived from internal of human ADCY5/6.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Immunohistochemistry analysis of paraffin-embedded human brain tissue using ADCY5/6 antibody.
Immunofluorescence analysis of HeLa cells, using ADCY5/6 antibody.
Background:
Membrane-bound, calcium-inhibitable adenylyl cyclase By similarity.
Synonyms:
ATP pyrophosphate-lyase; CYA6; Ca(2 )-inhibitable adenylyl cyclase; EC 4.6.1.1; KIAA0422
UniProt Protein Function:
ADCY6: a membrane-associated enzyme that catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Expressed in normal thyroid and brain tissues, as well as some tumors; its expression is significantly higher in one hyperfunctioning thyroid tumor than in normal thyroid tissue. Alternative splicing generates 2 transcript variants.Protein type: Nucleotide Metabolism - purine; EC 4.6.1.1; Transporter; Lyase; Adenylyl cyclase; Membrane protein, multi-pass; Transporter, aquaporin family; Membrane protein, integralChromosomal Location of Human Ortholog: 12q12-q13Cellular Component: membrane; plasma membrane; integral to membrane; ciliumMolecular Function: protein binding; metal ion binding; protein kinase binding; ATP binding; adenylate cyclase activityBiological Process: epidermal growth factor receptor signaling pathway; synaptic transmission; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; phospholipase C activation; water transport; activation of protein kinase A; dopamine receptor signaling pathway; energy reserve metabolic process; innate immune response; renal water homeostasis; cAMP biosynthetic process; G-protein signaling, adenylate cyclase inhibiting pathway; signal transduction; transmembrane transport; G-protein signaling, adenylate cyclase activating pathwayDisease: Lethal Congenital Contracture Syndrome 8
UniProt Protein Details:
NCBI Summary:
This gene encodes adenylate cyclase 6, which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). The expression of this gene is found in normal thyroid and brain tissues, as well as some tumors; and its expression is significantly higher in one hyperfunctioning thyroid tumor than in normal thyroid tissue. Alternative splicing generates 2 transcript variants. [provided by RefSeq, Jul 2008]
