Description
ADCY8 Antibody (PACO54630)
The ADCY8 Antibody (PAC054630) is a key tool for researchers studying the ADCY8 protein, which is an important enzyme involved in signal transduction pathways. This polyclonal antibody, produced in rabbits, exhibits high reactivity with human samples and is optimized for use in Western blot experiments.ADCY8, also known as adenylate cyclase 8, plays a critical role in cAMP signaling, which regulates various physiological processes including cell growth, differentiation, and hormone secretion.
By targeting the ADCY8 protein, researchers can gain valuable insights into the mechanisms underlying these cellular processes.This antibody is an essential tool for immunology and cell signaling studies, as well as for research into diseases where dysregulation of cAMP signaling is implicated. With its high specificity and sensitivity, the ADCY8 Antibody is a valuable resource for scientists exploring the role of ADCY8 in health and disease.
| Antibody Name: | ADCY8 Antibody (PACO54630) |
| Antibody SKU: | PACO54630 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:200-1:500 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Adenylate cyclase type 8 protein (534-670AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human brain tissue using PACO54630 at dilution of 1:100. |
 | Immunofluorescence staining of A549 cells with PACO54630 at 1:233, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human endometrial cancer using PACO54630 at dilution of 1:100. |
| Background: | This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence (By similarity). |
| Synonyms: | Adenylate cyclase type 8 (EC 4.6.1.1) (ATP pyrophosphate-lyase 8) (Adenylate cyclase type VIII) (Adenylyl cyclase 8) (AC8) (Ca(2+)/calmodulin-activated adenylyl cyclase), ADCY8 |
| UniProt Protein Function: | ADCY8: This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. |
| UniProt Protein Details: | Protein type:Nucleotide Metabolism - purine; Transporter; Membrane protein, multi-pass; Lyase; Membrane protein, integral; Transporter, aquaporin family; Adenylyl cyclase; EC 4.6.1.1 Chromosomal Location of Human Ortholog: 8q24 Cellular Component: membrane; integral to membrane; plasma membrane Molecular Function:metal ion binding; calcium- and calmodulin-responsive adenylate cyclase activity; ATP binding; adenylate cyclase activity Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; water transport; activation of protein kinase A; signal transduction; G-protein signaling, adenylate cyclase activating pathway; synaptic transmission; learning and/or memory; long-term memory; phospholipase C activation; energy reserve metabolic process; innate immune response; renal water homeostasis; cAMP biosynthetic process; G-protein signaling, adenylate cyclase inhibiting pathway; transmembrane transport |
| NCBI Summary: | Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase [provided by RefSeq, Jul 2008] |
| UniProt Code: | P40145 |
| NCBI GenInfo Identifier: | 729242 |
| NCBI Gene ID: | 114 |
| NCBI Accession: | P40145.1 |
| UniProt Related Accession: | P40145 |
| Molecular Weight: | 1251 |
| NCBI Full Name: | Adenylate cyclase type 8 |
| NCBI Synonym Full Names: | adenylate cyclase 8 (brain) |
| NCBI Official Symbol: | ADCY8Â Â |
| NCBI Official Synonym Symbols: | AC8; ADCY3; HBAC1Â Â |
| NCBI Protein Information: | adenylate cyclase type 8; adenylyl cyclase 8; ATP pyrophosphate-lyase 8; adenylyl cyclase-8, brain; adenylate cyclase type VIII; ca(2+)/calmodulin-activated adenylyl cyclase |
| UniProt Protein Name: | Adenylate cyclase type 8 |
| UniProt Synonym Protein Names: | ATP pyrophosphate-lyase 8; Adenylate cyclase type VIII; Adenylyl cyclase 8; AC8; Ca(2+)/calmodulin-activated adenylyl cyclase |
| Protein Family: | Adenylate cyclase |
| UniProt Gene Name: | ADCY8Â Â |
| UniProt Entry Name: | ADCY8_HUMAN |
