The ADO Antibody (PAC017494) offered by Assay Genie is a polyclonal antibody designed for research involving ADO, an important immune regulatory molecule. This antibody, produced in rabbits, is highly reactive with human samples and has been validated for use in various applications, including Western blotting. By binding to the ADO protein, this antibody enables accurate detection and analysis in different cell types, making it an ideal tool for studies in immunology, cancer research, and beyond.
ADO, also known as adenosine deaminase, is a key player in immune regulation, influencing processes such as inflammation and allergic responses. Its role in modulating immune responses has made it a target of interest in research related to diseases like cancer, autoimmune disorders, and chronic inflammatory conditions. Understanding the function of ADO is crucial for the development of potential therapies that can manipulate immune responses in these diseases.
Antibody Name:
ADO Antibody (PACO17494)
Antibody SKU:
PACO17494
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:1000-1:2000, WB:1:200-1:1000
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human ADO
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Gel: 8%SDS-PAGE,Lysate: 40 μg,,Primary antibody: PACO17494(ADO Antibody) at dilution 1/300 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 5 minutes.
Background:
Human thiol dioxygenases include cysteine dioxygenase (CDO, MIM 603943) and cysteamine (2-aminoethanethiol) dioxygenase (ADO, EC 1.13.11.19). CDO adds 2 oxygen atoms to free cysteine, whereas ADO adds 2 oxygen atoms to free cysteamine to form hypotaurine.
Synonyms:
2-aminoethanethiol dioxygenase
UniProt Protein Function:
ADO:
UniProt Protein Details:
Protein type:EC 1.13.11.19; Oxidoreductase; Other Amino Acids Metabolism - taurine and hypotaurine
Chromosomal Location of Human Ortholog: 10q21.3
Cellular Component: mitochondrion
Molecular Function:metal ion binding; cysteamine dioxygenase activity
NCBI Summary:
Human thiol dioxygenases include cysteine dioxygenase (CDO; MIM 603943) and cysteamine (2-aminoethanethiol) dioxygenase (ADO; EC 1.13.11.19). CDO adds 2 oxygen atoms to free cysteine, whereas ADO adds 2 oxygen atoms to free cysteamine to form hypotaurine (Dominy et al., 2007 [PubMed 17581819]).[supplied by OMIM, Mar 2008]
