The Adora3 Polyclonal Antibody (PACO3505) is a valuable tool for researchers studying the adenosine A3 receptor, a G-protein coupled receptor involved in various biological processes such as inflammation, immune response, and tissue protection. This antibody, generated in rabbits, demonstrates high specificity and sensitivity in detecting the Adora3 protein in human samples, making it suitable for use in Western blot applications.The Adora3 receptor plays a crucial role in regulating immune responses and inflammation by binding to adenosine, a signaling molecule involved in modulating various cellular functions.
Dysregulation of the Adora3 receptor has been linked to inflammatory disorders, neurodegenerative diseases, and cancer, making it a promising target for therapeutic interventions. By utilizing the Adora3 Polyclonal Antibody, researchers can investigate the expression and activity of the Adora3 receptor in different cell types and tissues, providing valuable insights for immunology and drug development studies.
Antibody Name:
ADORA3 Antibody
Antibody SKU:
PACO03505
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IF
Recommended Dilutions:
WB:1:500-1:2000, IF:1:200-1:1000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthesized peptide derived from the C-terminal region of human Adenosine A3-R.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
ADORA3; Adenosine receptor A3
UniProt Protein Function:
ADORA3: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. Possible role in reproduction. Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 1p13.2Cellular Component: mast cell granule; integral to plasma membrane; plasma membraneMolecular Function: adenosine receptor activity, G-protein coupledBiological Process: positive regulation of phosphoinositide 3-kinase cascade; histamine secretion by mast cell; positive regulation of leukocyte migration; adenylate cyclase activation; response to wounding; positive regulation of mast cell degranulation; positive regulation of calcium-mediated signaling; signal transduction; inflammatory response; adenosine receptor signaling pathway; regulation of heart contraction; positive regulation of inflammatory response
UniProt Protein Details:
NCBI Summary:
This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors that are involved in a variety of intracellular signaling pathways and physiological functions. The receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death. Alternative splicing results in multiple transcript variants. This gene shares its 5' terminal exon with some transcripts from overlapping GeneID:57413, which encodes an immunoglobulin domain-containing protein. [provided by RefSeq, Nov 2014]
