The AGBL2 Polyclonal Antibody (PAC036602) is a valuable tool for researchers studying AGBL2, a member of the AGBL family of proteins that play important roles in various cellular processes. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the AGBL2 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it ideal for studies in cell biology, biochemistry, and cancer research.
AGBL2 is known to be involved in regulating microtubule dynamics, protein degradation, and other critical cellular functions. Its role in these processes underscores its potential significance in diseases such as cancer, neurodegenerative disorders, and autoimmune conditions. By understanding the function of AGBL2, researchers can gain valuable insights into disease mechanisms and potentially identify new therapeutic targets for these conditions.
Western blot. All lanes: AGBL2 antibody at 8µg/ml + Mouse brain tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 105, 50, 33 kDa. Observed band size: 105 kDa.
Immunohistochemistry of paraffin-embedded human colon cancer using PACO36602 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human breast cancer using PACO36602 at dilution of 1:100.
Background:
Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Does not show detyrosinase or deglycylase activities from the carboxy-terminus of tubulin.
AGBL2: Metallocarboxypeptidase that may play a role in the processing of tubulin. Belongs to the peptidase M14 family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: EC 3.4.17.-; ProteaseChromosomal Location of Human Ortholog: 11p11.2Cellular Component: centriole; cytosolMolecular Function: zinc ion binding; metallocarboxypeptidase activityBiological Process: proteolysis
