The AGR3 Polyclonal Antibody (PAC015352) is a key tool for researchers studying AGR3, a protein associated with cancer progression and metastasis. This antibody is produced in rabbits and has high reactivity with human samples, making it an excellent choice for Western blot applications. By binding specifically to the AGR3 protein, this antibody allows for precise detection and analysis in various cell types, making it an essential tool for studies in oncology and cancer biology.AGR3, a member of the anterior gradient gene family, is known to play a crucial role in promoting tumor growth and metastasis in various types of cancer.
Understanding the functions and mechanisms of AGR3 is essential for developing targeted therapies for cancer treatment. Research on AGR3 may also provide insights into the development of diagnostic tools for early cancer detection. The AGR3 Polyclonal Antibody is a valuable asset for researchers seeking to advance our understanding of cancer biology and improve patient outcomes.
Antibody Name:
AGR3 Antibody (PACO15352)
Antibody SKU:
PACO15352
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:15-1:50
Species Reactivity:
Human, Mouse
Immunogen:
Fusion protein of human AGR3
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15352(AGR3 Antibody) at dilution 1/10, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO15352(AGR3 Antibody) at dilution 1/10, on the right is treated with fusion protein. (Original magnification: x200).
Background:
Anterior gradient protein 3 homolog is a protein that in humans is encoded by the AGR3 gene. The deduced 166-amino acid, protein has an N-terminal signal sequence. Fluorescence-tagged BCMP11 localized in secretory or endosome-like organelles in transfected breast carcinoma cell lines. Immunohistochemical analysis showed that expression of BCMP11 was restricted in normal tissues, with significant staining of only the epithelial lining of colonic mucosa. However, BCMP11 was detected in 43 of 58 (74%) breast cancer tissues tested, but not in normal breast ductal epithelial cells. In cancerous epithelial cells, BCMP11 localized to the cytoplasm.
Synonyms:
Anterior gradient 3 homolog (Xenopus laevis)
UniProt Protein Function:
AGR3: Belongs to the AGR family.Protein type: Secreted; Secreted, signal peptideChromosomal Location of Human Ortholog: 7p21.1Cellular Component: extracellular regionMolecular Function: protein binding
anterior gradient protein 3 homolog; AG-3; anterior gradient homolog 3; breast cancer membrane protein 11; protein disulfide isomerase family A, member 18
