The ALOX12 Polyclonal Antibody (CAB14703) is a valuable tool for researchers studying the ALOX12 protein, an enzyme involved in the metabolism of arachidonic acid and the generation of lipid mediators. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the ALOX12 protein, this antibody allows for the detection and analysis of ALOX12 in various cell types, making it an ideal choice for studies in inflammation, lipid metabolism, and cancer research.ALOX12 is known to play a crucial role in the production of pro-inflammatory lipid mediators, as well as in the resolution of inflammation through the generation of specialized pro-resolving lipid mediators.
Its involvement in these processes makes it a promising target for research into inflammatory diseases, such as asthma, atherosclerosis, and inflammatory bowel disease. By studying the function of ALOX12, researchers can gain valuable insights into the mechanisms underlying these conditions and potentially identify new therapeutic targets for treatment.
Product Name:
ALOX12 Rabbit Polyclonal Antibody
SKU:
CAB14703
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 483-663 of human ALOX12 (NP_000688.2).
This gene encodes a member of the lipoxygenase family of proteins. The encoded enzyme acts on different polyunsaturated fatty acid substrates to generate bioactive lipid mediators including eicosanoids and lipoxins. The encoded enzyme and its reaction products have been shown to regulate platelet function. Elevated expression of this gene has been observed in pancreatic islets derived from human diabetes patients. Allelic variants in this gene may be associated with susceptibility to toxoplasmosis. Multiple pseudogenes of this gene have been identified in the human genome.
Purification Method:
Affinity purification
Gene ID:
239
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from A-431 cells, using ALOX12 Rabbit pAb (CAB14703) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
