Description
ALX3 Antibody (PACO00390)
The ALX3 Polyclonal Antibody (PACO00390) is a high-quality research tool designed for studying the ALX3 protein, a transcription factor crucial for developmental processes, specifically in embryonic development. The antibody, produced in rabbits, exhibits strong reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the ALX3 protein, this antibody enables researchers to detect and analyze its expression in various cell types, making it an ideal tool for investigations in developmental biology and regenerative medicine.
ALX3, also known as aristaless-like homeobox 3, plays a key role in regulating gene expression during embryonic development, particularly in the formation of craniofacial structures and neural crest cells. Its importance in controlling developmental processes makes it a valuable target for research into birth defects, craniofacial abnormalities, and disorders of the central nervous system. Understanding the function of ALX3 is essential for developing potential therapeutic strategies to address developmental disorders and promote tissue regeneration in clinical settings.
| Antibody Name: | ALX3 Antibody |
| Antibody SKU: | PACO00390 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | synthesized peptide derived from the Internal region of human ALX3. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | ALX3; Homeobox protein aristaless-like 3; Proline-rich transcription factor ALX3 |
| UniProt Protein Function: | ALX3: Transcriptional regulator with a possible role in patterning of mesoderm during development. Defects in ALX3 are the cause of frontonasal dysplasia type 1 (FND1); also called frontonasal malformation (FNM) or frontorhiny. The term frontonasal dysplasia describes an array of abnormalities affecting the eyes, forehead and nose and linked to midfacial dysraphia. The clinical picture is highly variable. Major findings include true ocular hypertelorism; broadening of the nasal root; median facial cleft affecting the nose and/or upper lip and palate; unilateral or bilateral clefting of the alae nasi; lack of formation of the nasal tip; anterior cranium bifidum occultum; a V-shaped or widow's peak frontal hairline. Belongs to the paired homeobox family. |
| UniProt Protein Details: | Protein type:DNA-binding; Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 1p13.3 Cellular Component: nucleus Molecular Function:sequence-specific DNA binding Biological Process: regulation of apoptosis; embryonic forelimb morphogenesis; transcription, DNA-dependent; regulation of transcription, DNA-dependent; embryonic hindlimb morphogenesis; pattern specification process; embryonic skeletal morphogenesis Disease: Frontonasal Dysplasia 1 |
| NCBI Summary: | This gene encodes a nuclear protein with a homeobox DNA-binding domain that functions as a transcriptional regulator involved in cell-type differentiation and development. Preferential methylation of this gene's promoter is associated with advanced-stage neuroblastoma tumors. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O95076 |
| NCBI GenInfo Identifier: | 113204604 |
| NCBI Gene ID: | 257 |
| NCBI Accession: | NP_006483.2 |
| UniProt Related Accession: | O95076 |
| Molecular Weight: | |
| NCBI Full Name: | homeobox protein aristaless-like 3 |
| NCBI Synonym Full Names: | ALX homeobox 3 |
| NCBI Official Symbol: | ALX3Â Â |
| NCBI Official Synonym Symbols: | FND; FND1Â Â |
| NCBI Protein Information: | homeobox protein aristaless-like 3 |
| UniProt Protein Name: | Homeobox protein aristaless-like 3 |
| UniProt Synonym Protein Names: | Proline-rich transcription factor ALX3 |
| Protein Family: | Homeobox protein |
| UniProt Gene Name: | ALX3Â Â |
| UniProt Entry Name: | ALX3_HUMAN |
