Description
ANAPC4 Antibody (PACO07728)
The ANAPC4 Polyclonal Antibody (PACO07728) is a valuable tool for researchers studying the ANAPC4 protein, a key component of the anaphase promoting complex/cyclosome (APC/C). This antibody, produced in rabbits, demonstrates high specificity and reactivity with human samples, making it suitable for a variety of experimental applications, including Western blotting.ANAPC4 is essential for the regulation of cell cycle progression and overall cell division. Dysfunction of ANAPC4 has been associated with various diseases, including cancer, making it a target of interest for cancer research and drug development.
By using the ANAPC4 Polyclonal Antibody, researchers can investigate the role of ANAPC4 in cell cycle control, mitosis, and potential therapeutic interventions.With its ability to specifically bind to the ANAPC4 protein, this antibody enables precise detection and analysis in different cell types, providing valuable insights into cell cycle regulation mechanisms. Researchers in the fields of cell biology and oncology will find the ANAPC4 Polyclonal Antibody to be an indispensable tool for their studies and advancements in understanding disease pathways.
| Antibody Name: | ANAPC4 Antibody (PACO07728) |
| Antibody SKU: | PACO07728 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Human ANAPC4 |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| Purification Method: | Antigen Affinity purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | anaphase promoting complex subunit 4;ANAPC4;APC4 ; |
| UniProt Protein Function: | APC4: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Belongs to the APC4 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 4p15.2 Cellular Component: nucleoplasm; anaphase-promoting complex; nucleus; cytosol Molecular Function:protein binding; ubiquitin-protein ligase activity; protein phosphatase binding Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; mitosis; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; cell division; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; mitotic cell cycle spindle assembly checkpoint; mitotic cell cycle |
| NCBI Summary: | A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The exact function of this gene product is not known. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013] |
| UniProt Code: | Q9UJX5 |
| NCBI GenInfo Identifier: | 205371737 |
| NCBI Gene ID: | 29945 |
| NCBI Accession: | Q9UJX5.2 |
| UniProt Related Accession: | Q9UJX5 |
| Molecular Weight: | |
| NCBI Full Name: | Anaphase-promoting complex subunit 4 |
| NCBI Synonym Full Names: | anaphase promoting complex subunit 4 |
| NCBI Official Symbol: | ANAPC4Â Â |
| NCBI Official Synonym Symbols: | APC4Â Â |
| NCBI Protein Information: | anaphase-promoting complex subunit 4 |
| UniProt Protein Name: | Anaphase-promoting complex subunit 4 |
| UniProt Synonym Protein Names: | Cyclosome subunit 4 |
| Protein Family: | Acetophenone carboxylase |
| UniProt Gene Name: | ANAPC4Â Â |
| UniProt Entry Name: | APC4_HUMAN |
