The Anti-BCL2A1 Antibody (CAB0134) is a valuable tool for researchers studying the BCL2A1 protein, a member of the Bcl-2 family that plays a key role in apoptosis and cell survival. This polyclonal antibody is raised in rabbits and exhibits high reactivity specifically with human samples. Validated for use in Western blot applications, it binds to the BCL2A1 protein, allowing for accurate detection and analysis in a variety of cell types.BCL2A1, also known as Bfl-1, is a crucial regulator of cell survival and has been implicated in various diseases, including cancer and autoimmune disorders.
By targeting BCL2A1, researchers can gain valuable insights into the mechanisms underlying these diseases and potentially develop targeted therapies. This antibody is an essential tool for studies in cancer biology, immunology, and drug development, providing researchers with the means to investigate the role of BCL2A1 in disease progression and treatment.
Product Name:
BCL2A1 Polyclonal Antibody
SKU:
CAB0134
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 70-150 of human BCL2A1 (NP_004040.1).
This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
597
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Immunofluorescence analysis of Jurkat cells using BCL2A1 Rabbit pAb (CAB0134) at dilution of 1:200 (40x lens). Blue: DAPI for nuclear staining.
