The Anti-CD30 Ligand Recombinant Rabbit Monoclonal Antibody (HDAB0192) is a high-quality antibody designed for research involving CD30 Ligand, a cell surface molecule involved in immune regulation and inflammation. This antibody is raised in rabbits and is highly reactive with human samples, making it ideal for use in Western blot applications. By binding to the CD30 Ligand protein, this antibody enables the detection and analysis of CD30 Ligand in various cell types.CD30 Ligand, also known as tumor necrosis factor ligand superfamily member 8 (TNFSF8), is a critical player in immune responses, and its dysregulation has been associated with various diseases, including cancer and autoimmune disorders.
Research into CD30 Ligand is crucial for understanding its role in immune homeostasis and for developing potential therapies to modulate immune responses in disease contexts.The Anti-CD30 Ligand Recombinant Rabbit Monoclonal Antibody (HDAB0192) offers researchers a valuable tool for studying CD30 Ligand and its implications in immunology and cancer research. Its specificity and high reactivity with human samples make it an excellent choice for experiments aimed at uncovering the functions of CD30 Ligand in health and disease.
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30 lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene.
