The Anti-LAGE3 Antibody (CAB20546) is a valuable tool for researchers studying LAGE3, a protein involved in immune regulation and cancer development. This polyclonal antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the LAGE3 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it an essential component of immunology and cancer research studies.
LAGE3 is a critical player in immune response modulation, with its role in regulating inflammation and inhibiting allergic reactions making it a promising target for investigating diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. By gaining insights into the function of LAGE3, researchers can pave the way for developing innovative therapies that leverage or regulate immune responses in the context of these diseases.
Product Name:
LAGE3 Rabbit Polyclonal Antibody
SKU:
CAB20546
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-143 of human LAGE3 (NP_006005.2).
This gene belongs to the ESO/LAGE gene family, members of which are clustered together on chromosome Xq28, and have similar exon-intron structures. Unlike the other family members which are normally expressed only in testis and activated in a wide range of human tumors, this gene is ubiquitously expressed in somatic tissues. The latter, combined with the finding that it is highly conserved in mouse and rat, suggests that the encoded protein is functionally important. An intronless pseudogene with high sequence similarity to this gene is located on chromosome 9.
Purification Method:
Affinity purification
Gene ID:
8270
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using LAGE3 Rabbit pAb (CAB20546) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
