![Anti-Mouse CTLA-4 [9D9] In Vivo Antibody - Low Endotoxin](https://cdn11.bigcommerce.com/s-h68l9z2lnx/images/stencil/1280x1280/products/214407/569387/anti-mouse-ctla-4-9d9-in-vivo-antibody-low-endotoxin__60403.1770909495.jpg?c=2?imbypass=on "Anti-Mouse CTLA-4 [9D9] In Vivo Antibody - Low Endotoxin")
Description
Anti-Mouse CTLA-4 [9D9] In Vivo Antibody - Low Endotoxin
Introducing the Anti-Mouse CTLA-4 [9D9] In Vivo Antibody - Low Endotoxin from Assay Genie, a highly specific monoclonal antibody designed for in vivo applications. This antibody targets the CTLA-4 protein, a critical regulator of immune responses, making it ideal for research in immunology and related fields.
With a rat IgG2b isotype, it guarantees high purity and low endotoxin levels (<1.0 EU/mg), perfect for ELISA, flow cytometry, immunohistochemistry, and other assays. Available in various sizes, it is formulated in phosphate-buffered saline for stability and efficacy. Enhance your research with this reliable and versatile antibody. CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is an immune checkpoint receptor expressed primarily on T cells. It plays a significant role in downregulating immune responses, providing a crucial mechanism for maintaining immune homeostasis and preventing autoimmunity. CTLA-4 competes with the costimulatory receptor CD28 for binding to the B7 molecules (CD80/CD86) on antigen-presenting cells, thereby inhibiting T cell activation.
| Product Name: | Anti-Mouse CTLA-4 [9D9] In Vivo Antibody - Low Endotoxin |
| Product Code: | IVMB0072 |
| Size: | 1mg, 5mg, 25mg, 50mg, 100mg |
| Clone: | 9D9 |
| Protein: | CTLA-4 |
| Product Type: | Monoclonal Antibody |
| Synonyms: | CD152, Cytotoxic T Lymphocyte-Associated Antigen-4, Ly-56 |
| Isotype: | Mouse IgG2b |
| Reactivity: | Mouse |
| Applications: | FA, WB |
| Formulation: | This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. |
| Endotoxin Level: | < 1.0 EU/mg as determined by the LAL method |
| Purity: | ≥95% monomer by analytical SEC >95% by SDS Page |
| Preparation: | Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates. |
| Storage and Handling: | Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles. |
| Applications: | FA, WB |
| Reactivity: | Mouse |
| Host Species: | Mouse |
| Specificity: | Clone 9D9 recognizes an epitope on mouse CTLA-4. |
| Antigen Distribution: | CTLA-4 is expressed on activated T and B lymphocytes. |
| Concentration: | ≥ 5.0 mg/ml |
| Endotoxin Level: | < 1.0 EU/mg as determined by the LAL method |
| Purity: | ≥95% monomer by analytical SEC >95% by SDS Page |
| Formulation: | This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. |
| Preparation: | Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates. |
| Storage and Handling: | Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles. |
CTLA-4 is a 33 kD member of the Ig superfamily similar to CD28 in amino acid sequence, structure, and genomic organization. CTLA-4 is a protein receptor that functions as an immune checkpoint and downregulates immune responses. It is involved in the development of protective immunity and thymocyte regulation, in addition to the induction and maintenance of immunological tolerance. CTLA-4 has therapeutic potential both as an agonist to reduce immune activity, and an antagonist to increase immune activity.
| Technical Datasheet: | View |
| Protein: | CTLA-4 |
| Ligand/Receptor: | CD80 (B7.1), CD86 (B7.2) |
| Research Area: | Immunology, Inhibitory Molecules |
| Mouse IgG2b Isotype Control | |
|---|---|
| Clone | MPC-11 |
| Isotype | Mouse IgG2b kappa |
| Endotoxin Level | Low Endotoxin |
![Anti-Mouse CTLA-4 [9D9] In Vivo Antibody - Low Endotoxin](https://cdn11.bigcommerce.com/s-h68l9z2lnx/images/stencil/608x608/products/214407/569387/anti-mouse-ctla-4-9d9-in-vivo-antibody-low-endotoxin__60403.1770909495.jpg?c=2 "Anti-Mouse CTLA-4 [9D9] In Vivo Antibody - Low Endotoxin")
![Anti-Mouse CTLA-4 [9D9] In Vivo Antibody - Ultra Low Endotoxin](https://cdn11.bigcommerce.com/s-h68l9z2lnx/images/stencil/590x590/products/214408/569507/anti-mouse-ctla-4-9d9-in-vivo-antibody-ultra-low-endotoxin__11900.1770912807.jpg?c=2 "Anti-Mouse CTLA-4 [9D9] In Vivo Antibody - Ultra Low Endotoxin")
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