![Anti-Mouse CTLA-4 [9H10] In Vivo Antibody - Low Endotoxin](https://cdn11.bigcommerce.com/s-h68l9z2lnx/images/stencil/1280x1280/products/214382/569436/anti-mouse-ctla-4-9h10-in-vivo-antibody-low-endotoxin__38829.1770909942.jpg?c=2?imbypass=on "Anti-Mouse CTLA-4 [9H10] In Vivo Antibody - Low Endotoxin")
Description
Anti-Mouse CTLA-4 [9H10] In Vivo Antibody - Low Endotoxin
Introducing the Anti-Mouse CTLA-4 [9H10] In Vivo Antibody - Low Endotoxin from Assay Genie, a highly specific monoclonal antibody designed for in vivo applications. This antibody targets the CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) protein, an essential regulator of immune responses, making it ideal for research in immunology and related fields.
With a rat IgG2b isotype, it ensures high purity and low endotoxin levels (<1.0 EU/mg), perfect for ELISA, flow cytometry, immunohistochemistry, and other assays. Available in various sizes, it is formulated in phosphate-buffered saline for stability and efficacy. Enhance your research with this reliable and versatile antibody. CTLA-4 is a protein receptor found on the surface of T-cells. It functions as an immune checkpoint and downregulates immune responses. It plays a crucial role in modulating the immune system by transmitting inhibitory signals that regulate T-cell activation, ensuring immune homeostasis and preventing autoimmunity.
| Product Name: | Anti-Mouse CTLA-4 [9H10] In Vivo Antibody - Low Endotoxin |
| Product Code: | IVMB0047 |
| Size: | 1mg, 5mg, 25mg, 50mg, 100mg |
| Clone: | 9H10 |
| Protein: | CTLA-4 |
| Product Type: | Monoclonal Antibody |
| Synonyms: | CD152, Cytotoxic T Lymphocyte-Associated Antigen-4, Ly-56 |
| Isotype: | Syrian Hamster IgG |
| Reactivity: | Mouse |
| Immunogen: | Mouse CTLA-4-human IgG1 fusion protein |
| Applications: | B, WB |
| Formulation: | This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. |
| Endotoxin Level: | < 1.0 EU/mg as determined by the LAL method |
| Purity: | ≥95% monomer by analytical SEC >95% by SDS Page |
| Preparation: | Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates. |
| Storage and Handling: | Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles. |
| Applications: | B, WB |
| Reactivity: | Mouse |
| Host Species: | Syrian Hamster |
| Specificity: | Clone 9H10 recognizes an epitope on mouse CTLA-4. |
| Antigen Distribution: | CTLA-4 is expressed on activated T and B lymphocytes. |
| Immunogen: | Mouse CTLA-4-human IgG1 fusion protein |
| Concentration: | ≥ 5.0 mg/ml |
| Endotoxin Level: | < 1.0 EU/mg as determined by the LAL method |
| Purity: | ≥95% monomer by analytical SEC >95% by SDS Page |
| Formulation: | This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. |
| Preparation: | Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates. |
| Storage and Handling: | Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles. |
CTLA-4 is a 33 kD member of the Ig superfamily similar to CD28 in amino acid sequence, structure, and genomic organization. CTLA-4 is a protein receptor that functions as an immune checkpoint and downregulates immune responses. It is involved in the development of protective immunity and thymocyte regulation, in addition to the induction and maintenance of immunological tolerance. CTLA-4 has therapeutic potential both as an agonist to reduce immune activity, and an antagonist to increase immune activity.
| Technical Datasheet: | View |
| Protein: | CTLA-4 |
| Function: | Negative regulator of T cell activation |
| Ligand/Receptor: | CD80 (B7-1), CD86 (B7-2) |
| Research Area: | Immunology |
![Anti-Mouse CTLA-4 [9H10] In Vivo Antibody - Low Endotoxin](https://cdn11.bigcommerce.com/s-h68l9z2lnx/images/stencil/608x608/products/214382/569436/anti-mouse-ctla-4-9h10-in-vivo-antibody-low-endotoxin__38829.1770909942.jpg?c=2 "Anti-Mouse CTLA-4 [9H10] In Vivo Antibody - Low Endotoxin")
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