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Anti-PMEL Antibody (CAB5384)

SKU:
CAB5384
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
PMEL
D12S53E
ME20
ME20-M
ME20M
P1
P100
PMEL17
SI
SIL
SILV
gp100
$167 - $503
Frequently bought together:

Description

Product Name:PMEL Rabbit pAb
Product Code:CAB5384
Size:20uL, 50uL, 100uL
Synonyms:PMEL, D12S53E, ME20, ME20-M, ME20M, P1, P100, PMEL17, SI, SIL, SILV, gp100
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 25-300 of human PMEL (NP_008859.1).
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:A375
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 25-300 of human PMEL (NP_008859.1).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:KVPR NQDW LGVS RQLR TKAW NRQL YPEW TEAQ RLDC WRGG QVSL KVSN DGPT LIGA NASF SIAL NFPG SQKV LPDG QVIW VNNT IING SQVW GGQP VYPQ ETDD ACIF PDGG PCPS GSWS QKRS FVYV WKTW GQYW QVLG GPVS GLSI GTGR AMLG THTM EVTV YHRR GSRS YVPL AHSS SAFT ITDQ VPFS VSVS QLRA LDGG NKHF LRNQ PLTF ALQL HDPS GYLA EADL SYTW DFGD SSGT LISR ALVV THTY LEPG PVTA QVVL QAAI PLTS
Gene ID:6490
Uniprot:P40967
Cellular Location:Endoplasmic reticulum membrane, Endosome, Golgi apparatus, Melanosome, Secreted, Single-pass type I membrane protein, multivesicular body
Calculated MW:60kDa/66kDa/70kDa
Observed MW:80KDa/105KDa
UniProt Protein Function:SILV: Plays a central role in the biogenesis of melanosomes. Involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the appearance within of distinct fibrillar structures. Release of the soluble form, ME20-S, could protect tumor cells from antibody mediated immunity. Belongs to the PMEL/NMB family. 5 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Vesicle

Chromosomal Location of Human Ortholog: 12q13-q14

Cellular Component: Golgi apparatus; endoplasmic reticulum membrane; melanosome; plasma membrane; extracellular region; integral to membrane

Molecular Function:protein binding

Biological Process: melanin biosynthetic process; melanosome organization and biogenesis

NCBI Summary:This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2011]
UniProt Code:P40967
NCBI GenInfo Identifier:2507099
NCBI Gene ID:6490
NCBI Accession:P40967.2
UniProt Secondary Accession:P40967,Q12763, Q14448, Q14817, Q16565, B3KS57, B7Z6D7
UniProt Related Accession:P40967
Molecular Weight:70,255 Da
NCBI Full Name:Melanocyte protein PMEL
NCBI Synonym Full Names:premelanosome protein
NCBI Official Symbol:PMEL  
NCBI Official Synonym Symbols:P1; SI; SIL; ME20; P100; SILV; ME20M; gp100; ME20-M; PMEL17; D12S53E  
NCBI Protein Information:melanocyte protein PMEL; melanocyte protein mel 17; silver, mouse, homolog of; melanocyte protein Pmel 17; melanosomal matrix protein17; silver locus protein homolog; melanoma-associated ME20 antigen; melanocytes lineage-specific antigen GP100
UniProt Protein Name:Melanocyte protein PMEL
UniProt Synonym Protein Names:ME20-M; ME20M; Melanocyte protein Pmel 17; Melanocytes lineage-specific antigen GP100; Melanoma-associated ME20 antigen; P1; P100; Premelanosome protein; Silver locus protein homologCleaved into the following 2 chains:M-alpha; Alternative name(s):; 95 kDa melanocyte-specific secreted glycoprotein; P26; Secreted melanoma-associated ME20 antigen
UniProt Gene Name:PMEL  
UniProt Entry Name:PMEL_HUMAN

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