The AP3M2 Polyclonal Antibody (PAC024956) is a valuable tool for researchers studying AP3M2, a key protein involved in intracellular protein trafficking. This antibody, produced in rabbits, is highly specific and reacts with human samples, making it suitable for a variety of research applications such as Western blotting. By targeting the AP3M2 protein, this antibody allows for accurate detection and analysis in different cell types, making it an ideal choice for studies in cell biology and molecular biology.
AP3M2 is a critical component of the adaptor protein complex 3 (AP-3), which plays a crucial role in sorting proteins to specific destinations within the cell. Dysregulation of AP3M2 has been associated with various diseases, making it a promising target for research in areas such as neurodegenerative disorders and lysosomal storage diseases. Understanding the functions and mechanisms of AP3M2 is essential for unraveling its role in cellular processes and developing potential therapeutic interventions.
Antibody Name:
AP3M2 Antibody (PACO24956)
Antibody SKU:
PACO24956
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human AP-3 complex subunit mu-2 protein (1-273AA)
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using PACO24956 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human colon cancer using PACO24956 at dilution of 1:100.
Background:
Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
Synonyms:
AP-3 complex subunit mu-2 (Adaptor-related protein complex 3 subunit mu-2) (Clathrin assembly protein assembly protein complex 3 mu-2 medium chain) (Clathrin coat assembly protein AP47 homolog 2) (Clathrin coat-associated protein AP47 homolog 2) (Golgi adaptor AP-1 47 kDa protein homolog 2) (HA1 47 kDa subunit homolog 2) (Mu3B-adaptin) (P47B), AP3M2
UniProt Protein Function:
AP3M2: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Belongs to the adaptor complexes medium subunit family.Chromosomal Location of Human Ortholog: 8p11.2Cellular Component: Golgi apparatus; cytoplasmic vesicle membrane; clathrin adaptor complex; AP-type membrane coat adaptor complexBiological Process: intracellular protein transport; anterograde synaptic vesicle transport; anterograde axon cargo transport
UniProt Protein Details:
NCBI Summary:
This gene encodes a subunit of the heterotetrameric adaptor-related protein comlex 3 (AP-3), which belongs to the adaptor complexes medium subunits family. The AP-3 complex plays a role in protein trafficking to lysosomes and specialized organelles. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Aug 2008]
