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APC Anti-Human/Mouse KLRG-1 Antibody [2F1] (AGEL3109)

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SKU AGEL3109
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FCM
Reactivity Human
Reactivity Mouse
Host Species Syrian Hamster
Isotype Syrian Hamster IgG
Clone 2F1
Conjugation APC
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Description

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APC Anti-Human/Mouse KLRG-1 Antibody [2F1]

The KLRG-1 Monoclonal Antibody (2F1) is a powerful tool designed for research in immunology, specifically targeting the KLRG-1 protein expressed on human and mouse cells. This antibody, produced through rigorous development processes, is reactive with a range of samples and is validated for use in various applications such as flow cytometry and immunohistochemistry.KLRG-1, also known as killer cell lectin-like receptor G1, is a cell surface receptor involved in regulating immune responses, particularly in the context of T cell differentiation and function.

Its role in modulating immune cell activity highlights its importance in understanding immune system dynamics and its implications in diseases such as cancer and autoimmune disorders. By utilizing the KLRG-1 Monoclonal Antibody, researchers can accurately detect and analyze KLRG-1 expression, paving the way for in-depth investigations into immune regulation mechanisms and potential therapeutic targets.

Product Title:APC Anti-Human/Mouse KLRG-1 Antibody [2F1]
SKU:AGEL3109
Size:20 Tests, 100 Tests, 200 Tests
Clone No:2F1
Synonyms:MAFA; 2F1-Ag;
Host Species:Syrian Hamster
Reactivity:Human;Mouse
Application:FCM
Isotype:Syrian Hamster IgG
Form:Liquid
Conjugation:APC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:Q96E93 O88713
Gene ID:10219,50928
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:Killer cell lectin-like receptor G1 (KLRG1) is the mouse homolog of the rat mast cell function-associated antigen (MAFA or 2F1-Ag). KLRG1 is a type II membrane glycoprotein that was first identified on the surface of rat mast cell line RBL-2H3. It is composed of a homodimer of glycosylated 30-38 kD subunits. Mouse and human homologs of KLRG1 are expressed by subsets of NK cells and lymphokine-activated killer (LAK) cells but not mast cells. KLRG1 is also expressed on subsets of CD8+ and CD4+ cells, including CD4+ and CD8+ effector/memory cells, potent regulatory CD4+ T cells. KLRG1 may be involved in regulating NK cell homeostasis. KLRG6 was found to recognize cadherins and thus inhibit immune responses by regulating the effector function and the developmental processes of NK and T cells.

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