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APC Anti-Human/Mouse KLRG-1 Antibody [2F1] (AGEL3132)

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SKU AGEL3132
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FCM
Reactivity Human
Reactivity Mouse
Host Species Syrian Hamster
Isotype Syrian Hamster IgG
Clone 2F1
Conjugation APC
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Description

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APC Anti-Human/Mouse KLRG-1 Antibody [2F1]

The APC Anti-Human/Mouse KLRG-1 Antibody (2F1) from AssayGenie (catalog number AGEL3132) is a high-quality monoclonal antibody specifically designed for research applications involving the KLRG-1 protein in both human and mouse samples.KLRG-1, also known as killer cell lectin-like receptor G1, is a cell surface receptor expressed on subsets of T cells and natural killer cells. It is known to play a role in regulating immune responses, particularly in the context of T cell activation and differentiation. The 2F1 antibody, developed for optimal performance in flow cytometry and immunofluorescence applications, binds specifically to KLRG-1, allowing for precise detection and analysis in diverse cell populations.

Due to its role in immune regulation and potential implications in various diseases and conditions, such as infection, autoimmunity, and cancer, investigating the function of KLRG-1 is essential for advancing our understanding of immune responses and developing targeted therapies. The APC Anti-Human/Mouse KLRG-1 Antibody (2F1) provides researchers with a valuable tool for exploring the intricacies of KLRG-1-mediated immune modulation in different biological contexts.

Product Title:APC Anti-Human/Mouse KLRG-1 Antibody [2F1]
SKU:AGEL3132
Size:25µg, 100µg
Clone No:2F1
Synonyms:MAFA; 2F1-Ag;
Host Species:Syrian Hamster
Reactivity:Human;Mouse
Application:FCM
Isotype:Syrian Hamster IgG
Form:Liquid
Conjugation:APC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:Q96E93 O88713
Gene ID:10219,50928
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:Killer cell lectin-like receptor G1 (KLRG1) is the mouse homolog of the rat mast cell function-associated antigen (MAFA or 2F1-Ag). KLRG1 is a type II membrane glycoprotein that was first identified on the surface of rat mast cell line RBL-2H3. It is composed of a homodimer of glycosylated 30-38 kD subunits. Mouse and human homologs of KLRG1 are expressed by subsets of NK cells and lymphokine-activated killer (LAK) cells but not mast cells. KLRG1 is also expressed on subsets of CD8+ and CD4+ cells, including CD4+ and CD8+ effector/memory cells, potent regulatory CD4+ T cells. KLRG1 may be involved in regulating NK cell homeostasis. KLRG22 was found to recognize cadherins and thus inhibit immune responses by regulating the effector function and the developmental processes of NK and T cells.

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