The APLN Antibody (PAC020971) offered by Assay Genie is a high-quality polyclonal antibody designed for research involving APLN, a peptide hormone associated with cardiovascular functions and regulation of blood pressure. This antibody is raised in rabbits and exhibits high reactivity with human samples, making it suitable for various research applications.APLN, also known as apelin, is a key player in cardiovascular physiology, acting as a potent vasodilator and regulator of cardiac contractility. Its role in endothelial function and angiogenesis has also sparked interest in its potential therapeutic applications for cardiovascular diseases.
The APLN Antibody binds specifically to the APLN protein, allowing for accurate detection and analysis in different cell types and tissues.Research using the APLN Antibody can provide valuable insights into the mechanisms underlying cardiovascular disorders and help in the development of novel therapeutic strategies targeting the APLN signaling pathway. This antibody is validated for use in techniques such as Western blot, immunofluorescence, and immunohistochemistry, making it a versatile tool for studies in cardiovascular biology and related fields.
Antibody Name:
APLN Antibody (PACO20971)
Antibody SKU:
PACO20971
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:20-1:100
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic peptide of human APLN
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO20971(APLN Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20971(APLN Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a peptide that functions as an endogenous ligand for the G protein coupled receptor APJ. The encoded protein is synthesized as a prepropeptide that is processed into biologically active C-terminal fragments. The peptide fragments activate different tissue specific signaling pathways that regulate diverse biological functions including fluid homeostasis, cardiovascular function and insulin secretion. This protein also functions as a coreceptor for the human immunodeficiency virus 1.
Synonyms:
apelin
UniProt Protein Function:
apelin: Endogenous ligand for APJ, an alternative coreceptor with CD4 for HIV-1 infection. Inhibits HIV-1 entry in cells coexpressing CD4 and APJ. Apelin-36 has a greater inhibitory activity on HIV infection than other synthetic apelin derivatives. The oral intake in the colostrum and the milk could have a role in the modulation of the immune responses in neonates. May also have a role in the central control of body fluid homeostasis by influencing AVP release and drinking behavior. Belongs to the apelin family.
UniProt Protein Details:
Protein type:Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: Xq25
Cellular Component: extracellular space; extracellular region
Biological Process: lactation; immune response; signal transduction
NCBI Summary:
This gene encodes a peptide that functions as an endogenous ligand for the G protein coupled receptor APJ. The encoded protein is synthesized as a prepropeptide that is processed into biologically active C-terminal fragments. The peptide fragments activate different tissue specific signaling pathways that regulate diverse biological functions including fluid homeostasis, cardiovascular function and insulin secretion. This protein also functions as a coreceptor for the human immunodeficiency virus 1.[provided by RefSeq, Feb 2010]
