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Anti-Aquaporin 4 Antibody (CAB5665)

SKU:
CAB5665
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction
$167 - $503
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-Aquaporin 4 Antibody
Antibody SKU:CAB5665
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 244-323 of human Aquaporin 4 (NP_001641.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:Raji, Mouse kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 244-323 of human Aquaporin 4 (NP_001641.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:AGGL YEYV FCPD VEFK RRFK EAFS KAAQ QTKG SYME VEDN RSQV ETDD LILK PGVV HVID VDRG EEKK GKDQ SGEV LSSV
Gene ID:361
Uniprot:P55087
Cellular Location:Membrane, Multi-pass membrane protein
Calculated MW:32kDa/34kDa
Observed MW:30kDa
Synonyms:AQP4, MIWC, WCH4, aquaporin-4
Background:This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. This protein is the predominant aquaporin found in brain and has an important role in brain water homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon.
UniProt Protein Function:AQP4: a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. The predominant aquaporin found in brain. Two alternatively spliced transcript variants have been described
UniProt Protein Details:

Protein type:Transporter, aquaporin family; Membrane protein, integral; Channel, misc.; Membrane protein, multi-pass; Transporter

Chromosomal Location of Human Ortholog: 18q11.2-q12.1

Cellular Component: basolateral plasma membrane; cytoplasm; external side of plasma membrane; integral to membrane; plasma membrane

Molecular Function:glycerol channel activity; water channel activity; water transporter activity

Biological Process: glycerol transport; multicellular organismal water homeostasis; renal water homeostasis; transmembrane transport; transport; water transport

NCBI Summary:This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. This protein is the predominant aquaporin found in brain and has an important role in brain water homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2015]
UniProt Code:P55087
NCBI GenInfo Identifier:2506859
NCBI Gene ID:361
NCBI Accession:P55087.2
UniProt Secondary Accession:P55087,P78564,
UniProt Related Accession:P55087
Molecular Weight:32,300 Da
NCBI Full Name:Aquaporin-4
NCBI Synonym Full Names:aquaporin 4
NCBI Official Symbol:AQP4  
NCBI Official Synonym Symbols:MIWC; WCH4  
NCBI Protein Information:aquaporin-4
UniProt Protein Name:Aquaporin-4
UniProt Synonym Protein Names:Mercurial-insensitive water channel; MIWC; WCH4
Protein Family:Aquaporin
UniProt Gene Name:AQP4  
UniProt Entry Name:AQP4_HUMAN
Anti-Aquaporin 4 Antibody (CAB5665)Western blot - Aquaporin 4 Polyclonal Antibody (CAB5665)

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