The ARPP21 Polyclonal Antibody (PACO02365) is a valuable tool for researchers studying ARPP21, a protein involved in cell signaling pathways. This antibody, raised in rabbits, shows high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the ARPP21 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for studies in cell biology and signal transduction research.ARPP21, also known as cAMP-regulated phosphoprotein 21, is a key player in regulating cellular responses to various stimuli, including neurotransmitters and hormones.
Its involvement in signal transduction pathways makes it a promising target for research into neurological disorders, cancer, and other diseases characterized by dysregulated cell signaling. Investigating the function of ARPP21 can provide insights into potential therapeutic strategies that target these pathways for disease intervention.
Antibody Name:
ARPP21 Antibody
Antibody SKU:
PACO02365
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC
Recommended Dilutions:
WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:
Human, Mouse
Immunogen:
synthesized peptide derived from the Internal region of human ARPP-21.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons.
UniProt Protein Details:
NCBI Summary:
This gene encodes a cAMP-regulated phosphoprotein. The encoded protein is enriched in the caudate nucleus and cerebellar cortex. A similar protein in mouse may be involved in regulating the effects of dopamine in the basal ganglia. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
