The ASCC1 Antibody (CAB15832) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it a reliable tool for Western blot applications. By binding to ASCC1, this antibody allows for the precise detection and analysis of the protein in various cell types.ASCC1, also known as Activating Signal Cointegrator 1 Complex Subunit 1, plays a crucial role in maintaining genomic stability and preserving the integrity of DNA. Its function in DNA repair processes makes it a key player in preventing mutations and genomic alterations that can lead to diseases like cancer.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.
Product Name:
ASCC1 Antibody
SKU:
CAB15832
Size:
20μL, 100μL
Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:
p50, CGI-18, SMABF2, ASC1p50, ASCC1
Positive Sample:
Rat pancreas
Cellular Localization:
Cytoplasm.
Calculated MW:
46kDa
Observed MW:
46kDa
This gene encodes a subunit of the activating signal cointegrator 1 (ASC-1) complex. The ASC-1 complex is a transcriptional coactivator that plays an important role in gene transactivation by multiple transcription factors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF). The encoded protein contains an N-terminal KH-type RNA-binding motif which is required for AP-1 transactivation by the ASC-1 complex. Mutations in this gene are associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene.
Purification Method
Affinity purification
Gene ID
51008
RRID
AB_2763257
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from rat pancreas, using ASCC1 Rabbit pAb (CAB15832) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 10s.
