The ATR Monoclonal Antibody (CAB21253) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced through monoclonal antibody technology, demonstrates high specificity and sensitivity in detecting ATR in a variety of sample types, including human cells.ATR is a crucial protein involved in maintaining genomic stability and preventing the accumulation of mutations that can lead to cancer and other genetic disorders. By targeting ATR with this monoclonal antibody, researchers can explore the role of ATR in DNA repair processes, cell cycle regulation, and response to genotoxic stress.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse samples.
Product Name:
ATR Monoclonal Antibody
SKU:
CAB21253
Size:
20μL, 100μL
Reactivity:
Human, Mouse
Clone Number:
ARC51749
Conjugate:
Unconjugated
Immunogen:
Synthetic peptide. This information is considered to be commercially sensitive.
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:
FRP1, MEC1, SCKL, FCTCS, SCKL1, ATR
Positive Sample:
A-431, Mouse testis
Cellular Localization:
Chromosome, Nucleus, Pml Body.
Calculated MW:
301kDa
Observed MW:
301kDa
The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1.
Purification Method
Affinity purification
Gene ID
545
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates using ATR Rabbit mAb (CAB21253) at1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 180s.
