The BAF60A Polyclonal Antibody (CAB9950) is a vital tool for research involving BAF60A, a key subunit of the SWI/SNF chromatin remodeling complex. This antibody, derived from rabbit serum, has been extensively validated for its reactivity with human samples and is optimized for Western blot applications.BAF60A is a critical component of the SWI/SNF complex, which plays a crucial role in regulating gene expression and chromatin structure. Dysregulation of BAF60A has been implicated in various diseases, including cancer and neurological disorders, highlighting its importance in cellular function.By specifically targeting BAF60A, this polyclonal antibody enables researchers to study the role of this protein in various cell types and biological processes.
Its high specificity and sensitivity make it an ideal tool for investigations in the field of chromatin remodeling and gene regulation.Furthermore, a deeper understanding of BAF60A's function can provide valuable insights into disease mechanisms and potentially lead to the development of new therapeutic strategies targeting the SWI/SNF complex. Overall, the BAF60A Polyclonal Antibody (CAB9950) is a valuable asset for researchers interested in unraveling the complexities of gene regulation and chromatin dynamics.
Product Name:
BAF60a Rabbit Polyclonal Antibody
SKU:
CAB9950
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of mouse BAF60a (NP_114030.2).
Predicted to enable several functions, including chromatin binding activity; molecular adaptor activity; and transcription coregulator activity. Predicted to be involved in epigenetic maintenance of chromatin in transcription-competent conformation; nucleosome disassembly; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within chromatin organization and nervous system development. Part of SWI/SNF complex; nBAF complex; and npBAF complex. Is expressed in several structures, including central nervous system; dorsal root ganglion; early conceptus; genitourinary system; and retina layer. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome. Orthologous to human SMARCD1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1).
Purification Method:
Affinity purification
Gene ID:
83797
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using BAF60a Rabbit pAb (CAB9950) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 15s.
