Description
BBS7 Antibody (CAB17718)
The BBS7 Antibody (CAB17718) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody is raised in rabbits and exhibits high reactivity with human samples, making it an ideal choice for Western blot applications. By specifically binding to the BBS7 protein, researchers can easily detect and analyze this important molecule in various cell types.BBS7 is crucial for ciliary function and plays a role in various cellular processes, including protein trafficking and signaling pathways. Dysregulation of BBS7 has been linked to ciliary-related disorders such as Bardet-Biedl syndrome, making it a promising target for research in the field of ciliopathies.
This antibody is validated for use in WB, IF/ICC, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.
| Product Name: | BBS7 Antibody |
| SKU: | CAB17718 |
| Size: | 20μL, 100μL |
| Reactivity: | Human, Mouse, Rat |
| Conjugate: | Unconjugated |
| Immunogen: | Recombinant protein (or fragment).This information is considered to be commercially sensitive. | ||||||
| Sequence: | MDLI LNRM DYLQ VGVT SQKT MKLI PASR HRAT QKVV IGDH DGVV MCFG MKKG EAAA VFKT LPGP KIAR LELG GVIN TPQE KIFI AAAS EIRG FTKR GKQF LSFE TNLT ESIK AMHI SGSD LFLS ASYI YNHY CDCK DQHY YLSG DKIN DVIC LPVE RLSR ITPV LACQ DRVL RVLQ GSDV MYAV EVPG PPTV LALH NGNG GDSG EDLL FGTS DGKL ALIQ ITTS KPVR KWEI QNEK KRGG ILCI DSFD IVGD GVKD LLVG RDDG MVEV YS | ||||||
| Tested Applications: | WB IF/ICC ELISA | ||||||
| Recommended Dilution: |
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| Synonyms: | BBS2L1, BBS7 |
| Positive Sample: | Rat testis, Rat lung |
| Cellular Localization: | Axoneme, Bbsome, Centrosome, Ciliary Basal Body, Ciliary Membrane, Cytosol, Nucleus. |
| Calculated MW: | 80kDa |
| Observed MW: | 80kDa |
This gene encodes one of eight proteins that form the BBSome complex containing BBS1, BBS2, BBS4, BBS5, BBS7, BBS8, BBS9 and BBIP10. The BBSome complex is believed to recruit Rab8(GTP) to the primary cilium and promote ciliogenesis. The BBSome complex assembly is mediated by a complex composed of three chaperonin-like BBS proteins (BBS6, BBS10, and BBS12) and CCT/TRiC family chaperonins. Mutations in this gene are implicated in Bardet-Biedl syndrome, a genetic disorder whose symptoms include obesity, retinal degeneration, polydactyly and nephropathy; however, mutations in this gene and the BBS8 gene are thought to play a minor role and mutations in chaperonin-like BBS genes are found to be a major contributor to disease development in a multiethnic Bardet-Biedl syndrome patient population. Two transcript variants encoding distinct isoforms have been identified for this gene.
| Purification Method | Affinity purification |
| Gene ID | 55212 |
| RRID | AB_2768569 |
| Buffer Information | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |
 | Western blot analysis of various lysates using BBS7 Rabbit pAb (CAB17718) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 30s. |
