The Bcl-2 Polyclonal Antibody (CAB21592) is a valuable tool for researchers studying Bcl-2, a protein known for its role in regulating apoptosis, or programmed cell death. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the Bcl-2 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an excellent choice for studies in cancer biology and cell signaling pathways.Bcl-2 is a key regulator of cell survival and has been implicated in the pathogenesis of various diseases, including cancer and autoimmune disorders.
Understanding the function of Bcl-2 is essential for developing targeted therapies that can modulate cell death pathways and promote healthy cell growth. By using the Bcl-2 Polyclonal Antibody, researchers can gain valuable insights into the mechanisms underlying apoptosis and potentially discover new treatment strategies for diseases characterized by abnormal cell survival.
Product Name:
Bcl-2 Polyclonal Antibody
SKU:
CAB21592
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-239 of human Bcl-2 (NP_000624.2).
This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
596
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using [KD Validated] Bcl-2 Rabbit pAb (CAB21592) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
