The BCL6 Polyclonal Antibody (CAB7173) is a valuable tool for researchers studying BCL6, a transcriptional repressor protein involved in the regulation of B cell development and differentiation. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By targeting the BCL6 protein, this antibody allows for the detection and analysis of BCL6 expression in various cell types, making it a versatile tool for studies in immunology and cancer research.BCL6 is a critical regulator of B cell function, playing a key role in germinal center reactions and antibody class-switching.
Dysregulation of BCL6 expression has been linked to various lymphomas and leukemias, highlighting its importance in the pathogenesis of these diseases. Research on BCL6 can provide insights into the molecular mechanisms underlying B cell lymphomagenesis and inform the development of targeted therapies for B cell-related malignancies. By utilizing the BCL6 Polyclonal Antibody, researchers can further elucidate the functions of BCL6 in normal and pathological B cell biology.
Product Name:
BCL6 Rabbit Polyclonal Antibody
SKU:
CAB7173
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-280 of human BCL6 (NP_001124317.1).
The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
604
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of Raji cells, using BCL6 antibody (CAB7173) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
