The Biotinylated Anti-GITR Antibody (HDLA040) is a valuable tool for researchers studying GITR, a cell surface protein that plays a key role in regulating immune responses. This antibody, produced using high-quality biotin tagging technology, is highly specific for GITR and is capable of detecting and analyzing GITR expression in various cell types.GITR, also known as glucocorticoid-induced TNFR-related protein, is known to be a co-stimulatory molecule that enhances T cell activation and promotes immune responses.
Its involvement in regulating immune tolerance and promoting anti-tumor immunity makes it a promising target for cancer immunotherapy research. By using the Biotinylated Anti-GITR Antibody, researchers can gain valuable insights into the function of GITR and its potential as a therapeutic target in cancer and other immune-related diseases.
Product Code:
HDLA040
Size:
100 µg
Clonality:
Monoclonal
Clone:
DM78
Synonyms:
AITR, GITR, TNFRSF18, CD357
Applications:
ELISA, Flow Cyt
Recommended Dilution:
ELISA 1:5000-10000; Flow Cyt 1:100
Host Species:
Rabbit
Isotype:
Rabbit IgG
Reactivity:
Human
Purification Method:
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25( )CD4( ) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
