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Understanding the Bcl-2 Pathway: Implications for Cancer Therapy The Bcl-2 family of proteins plays a pivotal role in regulating apoptosis, a crucial process for maintaining cellular homeostasis. This article reviews the Bcl-2-regulated apoptotic pathway, highlighting its critical role in cell survival and death. Understanding these mechanisms is essential for developing targeted cancer therapies. Introduction Apoptosis, or programmed cell death, is a fundamental biological process that ensures the removal of damaged or unnecessary cells. The Bcl-2 family of proteins, including Bcl-2, Bcl-xL, and Bax, are key regulators of this pathway. Dysregulation of the …