The BNIP3L Polyclonal Antibody (CAB6283) is specifically designed for research involving BNIP3L, a cell protein involved in the regulation of apoptosis and mitochondrial function. This antibody, raised in rabbits, has high reactivity with human samples and is validated for use in Western blot applications. By binding to the BNIP3L protein, it enables the detection and analysis of BNIP3L in various cell types, making it ideal for studies in cell biology, apoptosis, and mitochondrial dysfunction research.BNIP3L, also known as BCL2/adenovirus E1B 19kDa protein-interacting protein 3-like, plays a crucial role in the regulation of programmed cell death by promoting mitochondria-mediated apoptosis.
Its involvement in mitochondrial quality control and cell survival makes it a key target for research into diseases like cancer, neurodegenerative disorders, and cardiovascular diseases. Understanding the function of BNIP3L is essential for developing therapies that target mitochondrial dysfunction and apoptosis-related pathologies.
Product Name:
BNIP3L Rabbit Polyclonal Antibody
SKU:
CAB6283
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 95-180 of human BNIP3L (NP_004322.1).
This gene encodes a protein that belongs to the pro-apoptotic subfamily within the Bcl-2 family of proteins. The encoded protein binds to Bcl-2 and possesses the BH3 domain. The protein directly targets mitochondria and causes apoptotic changes, including loss of membrane potential and the release of cytochrome c.
Purification Method:
Affinity purification
Gene ID:
665
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using BNIP3L Rabbit pAb (CAB6283) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
