Description
BRMS1 Antibody (PACO20997)
The BRMS1 Monoclonal Antibody (PACO20997) is a vital tool for researchers studying the BRMS1 protein, a metastasis suppressor gene implicated in cancer progression. This antibody, developed through monoclonal techniques, exhibits high specificity for human samples and is validated for use in various applications such as immunohistochemistry, immunofluorescence, and flow cytometry.BRMS1, also known as breast cancer metastasis suppressor 1, is a key player in inhibiting the spread of cancer cells to distant organs, making it a promising target for cancer therapy research. By targeting BRMS1 with this antibody, researchers can effectively detect and analyze the protein's expression levels in different cancer cell lines and tissues, providing valuable insights into its role in metastasis and potential therapeutic interventions.
The BRMS1 Monoclonal Antibody (PACO20997) offers a reliable tool for investigating the mechanisms underlying cancer metastasis and developing novel strategies for treating various types of cancer. Its specificity, sensitivity, and versatility make it an essential component of any research project aimed at understanding and combating cancer progression.
| Antibody Name: | BRMS1 Antibody (PACO20997) |
| Antibody SKU: | PACO20997 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthetic peptide of human BRMS1 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO20997(BRMS1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO20997(BRMS1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms. |
| Synonyms: | breast cancer metastasis suppressor 1 |
| UniProt Protein Function: | BRMS1: Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down- regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma. Belongs to the BRMS1 family. |
| UniProt Protein Details: | Protein type:Tumor suppressor Chromosomal Location of Human Ortholog: 11q13.2 Cellular Component: cytoplasm; nucleoplasm; nucleus Molecular Function:histone deacetylase activity; histone deacetylase binding; NF-kappaB binding; protein binding Biological Process: histone deacetylation; inhibition of NF-kappaB transcription factor; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent |
| NCBI Summary: | This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9HCU9 |
| NCBI GenInfo Identifier: | 18202959 |
| NCBI Gene ID: | 25855 |
| NCBI Accession: | Q9HCU9.1 |
| UniProt Secondary Accession: | Q9HCU9,Q6IAI2, |
| UniProt Related Accession: | Q9HCU9 |
| Molecular Weight: | 28,461 Da |
| NCBI Full Name: | Breast cancer metastasis-suppressor 1 |
| NCBI Synonym Full Names: | breast cancer metastasis suppressor 1 |
| NCBI Official Symbol: | BRMS1Â Â |
| NCBI Protein Information: | breast cancer metastasis-suppressor 1 |
| UniProt Protein Name: | Breast cancer metastasis-suppressor 1 |
| Protein Family: | Breast cancer metastasis-suppressor |
| UniProt Gene Name: | BRMS1Â Â |
| UniProt Entry Name: | BRMS1_HUMAN |
