The BRS3 Polyclonal Antibody (PAC019363) is a valuable tool for researchers studying BRS3, a G-protein coupled receptor involved in regulating energy homeostasis and metabolic disorders. This antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting BRS3 in human samples, making it ideal for use in Western blot experiments.BRS3, also known as Bombesin receptor subtype 3, plays a crucial role in modulating energy balance and food intake, making it a potential target for therapeutic interventions in obesity and related metabolic conditions. By targeting BRS3, researchers can gain insights into the mechanisms underlying energy regulation and explore novel strategies for managing metabolic disorders.
The BRS3 Polyclonal Antibody enables researchers to detect and analyze BRS3 expression in different cell types, providing valuable information for studies in metabolism, obesity, and energy regulation. Its high reactivity and specificity make it a reliable tool for investigating the role of BRS3 in physiological and pathological conditions, paving the way for potential therapeutic advancements in the field of metabolic research.
Antibody Name:
BRS3 Antibody (PACO19363)
Antibody SKU:
PACO19363
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic peptide of human BRS3
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO19363(BRS3 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO19363(BRS3 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
The protein encoded by this gene is a G protein-coupled membrane receptor that binds bombesin-like peptides. This binding results in activation of a phosphatidylinositol-calcium second messenger system, with physiological effects including regulation of metabolic rate, glucose metabolism, and hypertension.
Synonyms:
bombesin-like receptor 3
UniProt Protein Function:
BRS3: Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family.Protein type: Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR; Membrane protein, integralChromosomal Location of Human Ortholog: Xq26.3Cellular Component: neuron projection; cell soma; integral to membrane; plasma membraneMolecular Function: bombesin receptor activityBiological Process: regulation of blood pressure; bombesin receptor signaling pathway; glucose metabolic process; adult feeding behavior
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a G protein-coupled membrane receptor that binds bombesin-like peptides. This binding results in activation of a phosphatidylinositol-calcium second messenger system, with physiological effects including regulation of metabolic rate, glucose metabolism, and hypertension. [provided by RefSeq, Sep 2011]
