The BRS3 Polyclonal Antibody (PAC019364) is a valuable tool for researchers studying the BRS3 protein, a G protein-coupled receptor known for its role in regulating metabolism and energy expenditure. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the BRS3 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential component for studies in metabolic disorders and obesity research.
BRS3, also known as bombesin receptor subtype 3, plays a crucial role in the regulation of food intake and energy balance, making it a promising target for therapeutic interventions in metabolic diseases such as obesity and diabetes. Understanding the function of BRS3 is essential for developing novel treatments that modulate metabolic pathways and improve overall health outcomes. Researchers can rely on the BRS3 Polyclonal Antibody to aid in their investigations and further our understanding of metabolic regulation.
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO19364(BRS3 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200).
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: A172 cells, Primary antibody: PACO19364(BRS3 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO19364(BRS3 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
The protein encoded by this gene is a G protein-coupled membrane receptor that binds bombesin-like peptides. This binding results in activation of a phosphatidylinositol-calcium second messenger system, with physiological effects including regulation of metabolic rate, glucose metabolism, and hypertension.
Synonyms:
bombesin-like receptor 3
UniProt Protein Function:
BRS3: Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family.Protein type: Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR; Membrane protein, integralChromosomal Location of Human Ortholog: Xq26.3Cellular Component: neuron projection; cell soma; integral to membrane; plasma membraneMolecular Function: bombesin receptor activityBiological Process: regulation of blood pressure; bombesin receptor signaling pathway; glucose metabolic process; adult feeding behavior
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a G protein-coupled membrane receptor that binds bombesin-like peptides. This binding results in activation of a phosphatidylinositol-calcium second messenger system, with physiological effects including regulation of metabolic rate, glucose metabolism, and hypertension. [provided by RefSeq, Sep 2011]
