The CACNA1H Polyclonal Antibody is specifically designed for research involving the CACNA1H protein, which is a voltage-gated calcium channel essential for neuronal function and neurotransmitter release. This antibody, developed using rabbit polyclonal antibodies, is highly reactive with human samples and is validated for use in various applications such as Western blot and immunohistochemistry.CACNA1H, also known as Cav3.2, plays a crucial role in regulating calcium entry into neurons and is implicated in neurological disorders such as epilepsy, neuropathic pain, and psychiatric diseases. By targeting the CACNA1H protein, researchers can gain valuable insights into the mechanisms underlying these conditions and develop targeted therapies for treatment.
With its high specificity and sensitivity, the CACNA1H Polyclonal Antibody is an essential tool for studying the function and regulation of CACNA1H in neuronal cells, making it ideal for neuroscience and drug discovery research. By enabling precise detection and analysis of CACNA1H protein expression, this antibody offers a valuable resource for advancing our understanding of calcium signaling in the brain and its implications for neurological health.
Product Name:
CACNA1H Polyclonal Antibody
SKU:
CAB10697
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1890-2030 of human CACNA1H (NP_066921.2).
This gene encodes a T-type member of the alpha-1 subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. The alpha-1 subunit has 24 transmembrane segments and forms the pore through which ions pass into the cell. There are multiple isoforms of each of the proteins in the complex, either encoded by different genes or the result of alternative splicing of transcripts. Alternate transcriptional splice variants, encoding different isoforms, have been characterized for the gene described here. Studies suggest certain mutations in this gene lead to childhood absence epilepsy (CAE).
Purification Method:
Affinity purification
Gene ID:
8912
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Immunofluorescence analysis of NIH/3T3 cells using CACNA1H Rabbit pAb (CAB10697) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
