The CACNG5 Antibody (PACO08137) is a polyclonal antibody specifically designed for research involving the CACNG5 protein. CACNG5 is a member of the gamma-aminobutyric acid (GABA) receptor auxiliary subunit family and is known to play a role in regulating neuronal excitability and synaptic plasticity.This antibody is raised in rabbits and has shown high reactivity with human samples, making it ideal for use in various research applications such as Western blotting and immunohistochemistry. By binding to the CACNG5 protein, researchers can accurately detect and analyze its expression in different cell types, providing valuable insights into its function and potential implications in neurological disorders.
The CACNG5 Antibody is a valuable tool for studying the role of CACNG5 in neuronal signaling and synaptic transmission, making it particularly useful for research in neuroscience and neurology. Understanding the molecular mechanisms involving CACNG5 can lead to advancements in the development of therapies for neurological conditions such as epilepsy, schizophrenia, and Alzheimer's disease.
CACNG5: Regulates the gating properties of AMPA-selective glutamate receptors (AMPARs). Modulates their gating properties by accelerating their rates of activation, deactivation and desensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity for GRIA1, GRIA4 and the long isoform of GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.Protein type: Channel, calcium; Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 17q24Cellular Component: cell junction; plasma membrane; postsynaptic density; postsynaptic membraneMolecular Function: channel regulator activity; ion transmembrane transporter activity; voltage-gated calcium channel activityBiological Process: transmission of nerve impulse; transport
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a type II transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type I TARP and a calcium channel gamma subunit. This gene is a susceptibility locus for schizophrenia and bipolar disorder. [provided by RefSeq, Dec 2010]
