| UniProt Protein Function: | CACNG5: Regulates the gating properties of AMPA-selective glutamate receptors (AMPARs). Modulates their gating properties by accelerating their rates of activation, deactivation and desensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity for GRIA1, GRIA4 and the long isoform of GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.Protein type: Channel, calcium; Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 17q24Cellular Component: cell junction; plasma membrane; postsynaptic density; postsynaptic membraneMolecular Function: channel regulator activity; ion transmembrane transporter activity; voltage-gated calcium channel activityBiological Process: transmission of nerve impulse; transport |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is a type II transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type I TARP and a calcium channel gamma subunit. This gene is a susceptibility locus for schizophrenia and bipolar disorder. [provided by RefSeq, Dec 2010] |
| UniProt Code: | Q9UF02 |
| NCBI GenInfo Identifier: | 20532390 |
| NCBI Gene ID: | 27091 |
| NCBI Accession: | Q9UF02.2 |
| UniProt Secondary Accession: | Q9UF02,Q547R3, Q8WXS7, Q9UHM3, A8K2A6 |
| UniProt Related Accession: | Q9UF02 |
| Molecular Weight: | 30,903 Da |
| NCBI Full Name: | Voltage-dependent calcium channel gamma-5 subunit |
| NCBI Synonym Full Names: | calcium voltage-gated channel auxiliary subunit gamma 5 |
| NCBI Official Symbol: | CACNG5Â Â |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | voltage-dependent calcium channel gamma-5 subunit |
| UniProt Protein Name: | Voltage-dependent calcium channel gamma-5 subunit |
| UniProt Synonym Protein Names: | Neuronal voltage-gated calcium channel gamma-5 subunit; Transmembrane AMPAR regulatory protein gamma-5; TARP gamma-5 |
| Protein Family: | Voltage-dependent calcium channel |
| UniProt Gene Name: | CACNG5Â Â |
| UniProt Entry Name: | CCG5_HUMAN |
