The Calca Polyclonal Antibody (PAC019218) is a valuable tool for research involving the Calca gene, which encodes for calcitonin-related polypeptide alpha, a peptide hormone with diverse physiological functions. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications, including immunohistochemistry and ELISA.Calca, also known as CALC1, is involved in the regulation of calcium metabolism, bone development, and pain perception. It is expressed in several tissues, including the thyroid, brain, and sensory neurons, pointing to its roles in both endocrine and neuronal functions.
Research on Calca is crucial for advancing our understanding of diseases such as osteoporosis, chronic pain, and neurological disorders.The Calca Polyclonal Antibody enables the detection and analysis of Calca protein expression in different tissue types, providing valuable insights into its physiological roles and potential therapeutic implications. Its versatility and specificity make it an essential tool for studies in endocrinology, neuroscience, and pain research.
Antibody Name:
CALCA Antibody (PACO19218)
Antibody SKU:
PACO19218
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human CALCA
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO19218(CALCA Antibody) at dilution 1/60, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms:
calcitonin-related polypeptide alpha
UniProt Protein Function:
CALCA: Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones. Belongs to the calcitonin family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:
Protein type:Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 11p15.2
Cellular Component: extracellular region; extracellular space
Molecular Function:calcitonin receptor binding; identical protein binding; protein binding
Biological Process: activation of protein kinase activity; cellular protein metabolic process; elevation of cytosolic calcium ion concentration; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); embryo implantation; monocyte chemotaxis; negative regulation of bone resorption; negative regulation of transcription, DNA-dependent; positive regulation of adenylate cyclase activity
NCBI Summary:
This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2014]
