The CALCRL Antibody (CAB8533) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody is produced in rabbits and is highly specific to human samples, making it an ideal choice for Western blot applications. By binding to CALCRL, this antibody allows for precise detection and analysis in a variety of cell types, making it a valuable asset for studies in cardiology, neurology, and vascular biology.CALCRL, also known as calcitonin gene-related peptide receptor-like receptor, plays a crucial role in vasodilation, pain transmission, and neurotransmitter release. Its involvement in these processes makes it a key target for research into cardiovascular diseases, migraine headaches, and neuronal disorders.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.
Product Name:
CALCRL Antibody
SKU:
CAB8533
Size:
20μL, 100μL
Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Immunogen:
Synthetic peptide. This information is considered to be commercially sensitive.
Sequence:
PGYS HDCP SEHL NGKS
Tested Applications:
WBELISA
Recommended Dilution:
WB
1:500 - 1:2000
ELISA
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:
CRLR, CGRPR, LMPHM8, CALCRL
Positive Sample:
A-549, MCF7, Mouse kidney, Mouse liver, Rat liver
Cellular Localization:
Cell Membrane, Multi-Pass Membrane Protein.
Calculated MW:
53kDa
Observed MW:
43kDa
Enables adrenomedullin binding activity; adrenomedullin receptor activity; and calcitonin gene-related peptide receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; cellular response to sucrose stimulus; and receptor internalization. Located in endoplasmic reticulum; endosome; and lysosome. Part of CGRP receptor complex and adrenomedullin receptor complex. Colocalizes with plasma membrane. Implicated in hereditary lymphedema.
Purification Method
Affinity purification
Gene ID
10203
RRID
AB_2768686
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates using CALCRL Rabbit pAb (CAB8533) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 15s.
