The CCRL2 Polyclonal Antibody is a essential tool for research involving CCRL2, a chemokine receptor implicated in immune responses and inflammation. This antibody is produced in rabbits and is highly specific for human samples, making it a great choice for studies focusing on CCRL2 in various cell types. It has been validated for use in Western blot applications, enabling accurate detection and analysis of the CCRL2 protein.CCRL2, also known as chemokine-like receptor 2, plays a critical role in immune cell trafficking and inflammation regulation. Its involvement in these processes makes it a key target for research in immunology and inflammatory diseases.
Understanding the function of CCRL2 can provide valuable insights into the development of treatments for conditions such as autoimmune disorders and chronic inflammatory diseases.Overall, the CCRL2 Polyclonal Antibody is a reliable tool for researchers looking to investigate the role of CCRL2 in immune responses and inflammation. Its specificity for human samples and efficacy in Western blot applications make it an ideal choice for studies in immunology and inflammation research.
Western Blot. Positive WB detected in: HL60 whole cell lysate. All lanes: CCRL2 antibody at 2.5µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 40, 41 kDa. Observed band size: 40 kDa.
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO54686 at dilution of 1:100.
Background:
Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptors. Plays a critical role for the development of Th2 responses.
CCRL2: Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptors. Plays a critical role for the development of Th2 responses. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCRChromosomal Location of Human Ortholog: 3p21Cellular Component: integral to plasma membrane; plasma membraneMolecular Function: CCR chemokine receptor binding; chemokine receptor bindingBiological Process: inflammatory response
UniProt Protein Details:
NCBI Summary:
This gene encodes a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. This gene is mapped to the region where the chemokine receptor gene cluster is located. [provided by RefSeq, Jul 2008]
