The CD152 Polyclonal Antibody is a key tool for researchers studying CD152, a crucial immune regulatory molecule that plays a significant role in inhibiting immune responses. This polyclonal antibody, produced in rabbits, is highly specific for human samples and has been rigorously validated for Western blot applications. By binding to the CD152 protein, researchers can easily detect and analyze its expression in various cell types, making it ideal for studies in immunology and cancer research.CD152, also known as CTLA-4, is a pivotal immune checkpoint receptor that acts as a negative regulator of T-cell activation, playing a vital role in maintaining immune tolerance and preventing autoimmunity.
The importance of CD152 in immune regulation underscores its relevance in diseases such as cancer, autoimmune disorders, and inflammatory conditions. Insights into the function of CD152 are crucial for the development of therapeutic strategies targeting immune responses in these disease contexts.Overall, the CD152 Polyclonal Antibody serves as a valuable tool for researchers investigating the role of CD152 in immune regulation, making it an essential component for studies aimed at advancing our understanding of immune responses and developing targeted therapies for various immune-related disorders.
Product Name:
CD152 Polyclonal Antibody
SKU:
CAB24845
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant Protein corresponding to a sequence within amino acids 36-161 of mouse CD152(NP_033973.2).
Genetic variation in CTLA4 influences susceptibility to systemic lupus erythematosus (SLE) [MIM:152700]. SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. SLE is thought to represent a failure of the regulatory mechanisms of the autoimmune system._x000D_ Note=Genetic variations in CTLA4 may influence susceptibility to Graves disease, an autoimmune disorder associated with overactivity of the thyroid gland and hyperthyroidism._x000D_ Genetic variation in CTLA4 is the cause of susceptibility to diabetes mellitus insulin-dependent type 12 (IDDM12) [MIM:601388]. A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels._x000D_ Genetic variation in CTLA4 is the cause of susceptibility to celiac disease type 3 (CELIAC3) [MIM:609755]. It is a multifactorial disorder of the small intestine that is influenced by both environmental and genetic factors. It is characterized by malabsorption resulting from inflammatory injury to the mucosa of the small intestine after the ingestion of wheat gluten or related rye and barley proteins. In its classic form, celiac disease is characterized in children by malabsorption and failure to thrive.
Purification Method:
Affinity purification
Gene ID:
12477
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type (WT) and 293T cells transfected with CD152 using CD152 Rabbit pAb(CAB24845) at 1:1000 dilution.Secondary antibody:HRP Goat Anti-Rabbit IgG (H+L)(CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection:ECL Basic Kit (AbGn00020).Exposuretime: 10s.
