Description
system_update_altDatasheet
| Product Name: | CD19 monoclonal antibody (APC) |
| Product Code: | AGIM0464 |
| Size: | 100 µL |
| Reactivity: | Human |
| Clone: | LT19 |
| Applications: | Flow Cytometry |
| Conjugate: | APC |
| Isotype: | IgG1 |
| Host Species: | Mouse |
| Storage: | Store at 4° C. Do not freeze. Avoid prolonged exposure to light. |
| Uniprot: | P15391 |
| Background: | CD19 is a transmembrane glycoprotein of Ig superfamily expressed by B cells from the time of heavy chain rearrangement until plasma cell differentiation. It forms a tetrameric complex with CD21 (complement receptor type 2), CD81 (TAPA-1) and Leu13. Together with BCR (B cell antigen receptor), this complex signals to decrease B cell treshold for activation by the antigen. Besides being signal-amplifying coreceptor for BCR, CD19 can also signal independently of BCR coligation and it turns out to be a central regulatory component upon which multiple signaling pathways converge. Mutation of the CD19 gene results in hypogammaglobulinemia, whereas CD19 overexpression causes B cell hyperactivity. |
| UniProt Protein Function: | Assembles with the antigen receptor of B-lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. |
| NCBI Summary: | Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P15391 |
| NCBI GenInfo Identifier: | 160332376 |
| NCBI Gene ID: | 930 |
| NCBI Accession: | P15391.6 |
| UniProt Secondary Accession: | P15391,Q96S68, Q9BRD6, A0N0P9, F5H635, |
| UniProt Related Accession: | P15391 |
| Molecular Weight: | |
| NCBI Full Name: | B-lymphocyte antigen CD19 |
| NCBI Synonym Full Names: | CD19 molecule |
| NCBI Official Symbol: | CD19Â Â |
| NCBI Official Synonym Symbols: | B4; CVID3Â Â |
| NCBI Protein Information: | B-lymphocyte antigen CD19 |
| UniProt Protein Name: | B-lymphocyte antigen CD19 |
| UniProt Synonym Protein Names: | B-lymphocyte surface antigen B4; Differentiation antigen CD19; T-cell surface antigen Leu-12; CD_antigen: CD19 |
| Protein Family: | B-lymphocyte antigen |
| UniProt Gene Name: | CD19Â Â |
