Description
system_update_altDatasheet
| Product Name: | CD49d monoclonal antibody (PE) |
| Product Code: | AGIM0365 |
| Size: | 100 µL |
| Reactivity: | Human |
| Clone: | PS/2 |
| Applications: | Flow Cytometry |
| Conjugate: | PE |
| Isotype: | IgG2b |
| Host Species: | Rat |
| Storage: | Store at 4°C. Avoid prolonged exposure to light. |
| Uniprot: | Q00651 |
| Background: | Integrins alpha-4/beta-1 (VLA-4 or LPAM-2) and alpha-4/beta-7 (LPAM-1) are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. Integrin alpha4/beta-7 is also a receptor for MADCAM1. Mice homozygous for a null mutation of the alpha-4 subunit gene die by day E11-E14 from detachment and rupture of the epicardium and coronary arteries. |
| UniProt Code: | Q00651 |
| NCBI GenInfo Identifier: | 114326554 |
| NCBI Gene ID: | 16401 |
| NCBI Accession: | NP_034706.3 |
| UniProt Related Accession: | Q00651 |
| Molecular Weight: | 115,696 Da |
| NCBI Full Name: | integrin alpha-4 |
| NCBI Synonym Full Names: | integrin alpha 4 |
| NCBI Official Symbol: | Itga4Â Â |
| NCBI Official Synonym Symbols: | CD49D; Itga4BÂ Â |
| NCBI Protein Information: | integrin alpha-4; CD49 antigen-like family member D; LPAM subunit alpha; VLA-4 receptor, alpha 4 subunit; VLA-4 subunit alpha; integrin alpha-IV; integrin alpha4B; lymphocyte Peyer patch adhesion molecules subunit alpha |
| UniProt Protein Name: | Integrin alpha-4 |
| UniProt Synonym Protein Names: | CD49 antigen-like family member D; Integrin alpha-IV; Lymphocyte Peyer patch adhesion molecules subunit alpha; LPAM subunit alpha; VLA-4 subunit alpha; CD_antigen: CD49d |
| UniProt Gene Name: | Itga4Â Â |
| UniProt Entry Name: | ITA4_MOUSE |
