The CDKN2C/p18-INK4C Antibody (CAB12418) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications.CDKN2C, also known as p18, plays a crucial role in controlling cell division and proliferation by inhibiting cyclin-dependent kinases. Dysregulation of CDKN2C has been linked to various types of cancers, making it a potential target for cancer therapy research.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse samples.
Product Name:
CDKN2C/p18-INK4C Antibody
SKU:
CAB12418
Size:
20μL, 100μL
Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:
p18, INK4C, p18-INK4C, CDKN2C/p18-INK4C
Positive Sample:
THP-1, Raji, Mouse testis, Mouse spleen
Cellular Localization:
Cytoplasm, Cytosol, Nucleus.
Calculated MW:
18kDa
Observed MW:
18kDa
The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported.
Purification Method
Affinity purification
Gene ID
1031
RRID
AB_2759259
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates using CDKN2C/p18-INK4C Rabbit pAb (CAB12418) at 1:500 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (AbGn00021). Exposure time: 90s.
