Based on the information provided in the URL, the CHST9 Antibody (PACO05462) is a polyclonal antibody designed for research involving CHST9, an enzyme that plays a key role in the sulfation of glycosaminoglycans. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications, including Western blotting.CHST9 is involved in the modification of sugar molecules on proteins and plays a crucial role in the regulation of various biological processes, including cell signaling and communication. Research into CHST9 is important for understanding its function in health and disease, particularly in the context of cancer and other diseases characterized by abnormal glycosaminoglycan sulfation.
The CHST9 Antibody (PACO05462) enables the detection and analysis of CHST9 protein in different cell types, making it a valuable tool for studies in glycobiology, cancer research, and other areas of biomedical research. By studying the role of CHST9 in cellular processes and disease pathology, researchers can gain insight into potential therapeutic targets and develop new treatment strategies.
Antibody Name:
CHST9 Antibody (PACO05462)
Antibody SKU:
PACO05462
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC, IF
Recommended Dilutions:
ELISA:1:20000, IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:
Human, Mouse
Immunogen:
Synthesized peptide derived from the C-terminal region of human CHST9.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
CHST9: Catalyzes the transfer of sulfate to position 4 of non- reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Participates in biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Has a higher activity toward carbonic anhydrase VI than toward lutropin. Only active against terminal GalNAcbeta1,GalNAcbeta. Isoform 2, but not isoform 1, is active toward chondroitin. Belongs to the sulfotransferase 2 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Transferase; Membrane protein, integral; EC 2.8.2.-Chromosomal Location of Human Ortholog: 18q11.2Cellular Component: Golgi membraneMolecular Function: chondroitin 4-sulfotransferase activity; N-acetylgalactosamine 4-O-sulfotransferase activityBiological Process: chondroitin sulfate biosynthetic process; hormone biosynthetic process; proteoglycan biosynthetic process; sulfur metabolic process
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Sulfate groups on carbohydrates confer highly specific functions to glycoproteins, glycolipids, and proteoglycans, and are critical for cell-cell interaction, signal transduction, and embryonic development. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Aug 2011]
