The Cleaved EFNA2 (N188) Antibody (PACO00028) is a valuable tool for researchers studying EFNA2, a protein involved in cell signaling and development. This antibody, produced in rabbits, has a high affinity for human EFNA2 and has been validated for use in Western blot applications. By binding specifically to the cleaved form of EFNA2, this antibody allows for the detection and analysis of EFNA2 in various cell types, making it an excellent choice for studies in developmental biology and cancer research.EFNA2 is known to play a crucial role in regulating cell adhesion and migration, as well as promoting cell survival and proliferation.
Understanding the role of cleaved EFNA2 in these processes can provide insights into how this protein contributes to normal development and disease progression. Research on EFNA2 has implications for a wide range of fields, including cancer biology, neurobiology, and regenerative medicine.Overall, the Cleaved EFNA2 (N188) Antibody (PACO00028) is a valuable tool for researchers interested in unraveling the complex functions of EFNA2 in various biological processes. Its specificity and sensitivity make it an excellent choice for investigating the role of EFNA2 in health and disease.
Antibody Name:
Cleaved-EFNA2 (N188) Antibody
Antibody SKU:
PACO00028
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human, Mouse
Immunogen:
synthesized peptide derived from the C-terminal region of human Ephrin-A2.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
EFNA2: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. With the EPHA2 receptor may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis. Belongs to the ephrin family.Protein type: Membrane protein, GPI anchor; Ligand, receptor tyrosine kinaseChromosomal Location of Human Ortholog: 19p13.3Cellular Component: extracellular region; plasma membrane; perikaryon; neuromuscular junctionMolecular Function: ephrin receptor bindingBiological Process: axon guidance; cell-cell signaling; olfactory bulb development; ephrin receptor signaling pathway; osteoclast differentiation; bone remodeling
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the ephrin family. The protein is composed of a signal sequence, a receptor-binding region, a spacer region, and a hydrophobic region. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. Posttranslational modifications determine whether this protein localizes to the nucleus or the cytoplasm. [provided by RefSeq, Jul 2008]
